IMMU-15. QUANTIFYING INTRATHECAL DRUG DELIVERY UTILIZING PROGRAMMABLE VENTRICULOPERITONEAL SHUNTS
نویسندگان
چکیده
منابع مشابه
Ventriculoperitoneal shunts to control hydrocephalus in adults
Hydrocephalus is a neurological disorder where there is an increased build up of cerebrospinal fluid (CSF) in the brain. One of the most prominent ways to treat this condition is the use of a ventriculoperitoneal (VP) shunt. Studies conducted are used to understand what the best treatment will be for certain patients with hydrocephalus. The overall goal of these studies is to determine how tech...
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The aim of this principally experimental study is to understand from fluid mechanic principles why an insignificant anesthetic dose administered as a short bolus into the cerebrospinal fluid inside the subarachnoid space provides greater pain relief than a larger dose continuously injected over a longer period. The subarachnoid space is modeled as an annular gap of constant or slowly varying cr...
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Transporters play important roles in tissue distribution and urinary- and biliary-excretion of drugs and transporter molecules involved in those processes have been elucidated well. Furthermore, an involvement of efflux transporters such as P-glycoproteins, multidrug resistance associated protein 2, and breast cancer resistance protein as the intestinal absorption barrier and/or intestinal lumi...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2021
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/noab090.122